Quantitative differential diagnostics in dementia
cNeuro® cDSI is a tool for clinical decision support in dementia based on combination of imaging, lab results and clinical data.
- Cloud-based tool running in a standard browser.
- Comparison of patient’s data to data from previously diagnosed patients providing a quantitative estimate about patient’s similarity to different disease groups.
- Intuitive and interactive visualization of the similarity.
- Decision models available for etiology and progression.
- Patient data supported: clinical and neuropsychological test data, MRI imaging biomarkers, CSF biomarkers and APOE gene.
- Cloud-based – software runs in a standard web browser.
- Computation of disease state index measuring the similarity of the patient to previously diagnosed patients.
- Data sources supported:
- Clinical and neuropsychological tests: MMSE, RAVLT/CERAD recall & delayed recall, TMT A&B, Animal fluency, NPI.
- MRI imaging biomarkers from cMRI: volumes, computed MTA, GCA (global and local), Fazekas.
- Biomarkers: CSF biomarkers, APOE.
- Decision models available:
- Etiology: Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), vascular dementia (VaD), cognitively normal (CN).
- Progression: stable and progressive mild cognitive impairment.
- Compact visualization of all data using the patented disease state fingerprint technology.
List of publications
SELECTED PUBLICATIONS RELEVANT TO cDSI
T. Pekkala et al. Detecting amyloid positivity in elderly with increased risk of cognitive decline. Frontiers in Aging Neuroscience, 2020. https://doi.org/10.3389/fnagi.2020.00228
Rhodius-Meester et al. A computer-supported decision approach to select memory clinic patients for CSF testing. PLoS ONE, 2020. https://doi.org/10.1371/journal.pone.0226784
M. Bruun et al. Impact of a clinical decision support tool on dementia diagnostics in memory clinics, The PredictND validation study. Current Alzheimer Research, 2019. https://doi.org/10.2174/1567205016666190103152425
Rhodius-Meester et al. Computer-assisted prediction of clinical progression in the earliest stages of AD. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018. https://www.sciencedirect.com/science/article/pii/S2352872918300666
Bruun et al. Evaluating combinations of diagnostic tests to discriminate different dementia types. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018. https://doi.org/10.1016/j.dadm.2018.07.003
Tolonen et al. Data-driven differential diagnosis of dementia using multiclass Disease State Index. Frontiers in Aging Neuroscience, 2018. https://doi.org/10.3389/fnagi.2018.00111
Rhodius-Meester et al. Integrating biomarkers for underlying Alzheimer’s disease in mild cognitive impairment in daily practice: Comparison of a clinical decision support system with individual biomarkers. Journal of Alzheimer’s Disease, 2016. https://doi.org/10.3233/JAD-150548
Hall et al. Generalizability of the Disease State Index Prediction Model for Identifying Patients Progressing from Mild Cognitive Impairment to Alzheimer’s Disease. Journal of Alzheimer’s Disease, 2015. https://doi.org/10.3233/JAD-140942
Hall et al. Predicting Progression from Cognitive Impairment to Alzheimer’s Disease with the Disease State Index. Current Alzheimer Research, 2015. https://doi.org/10.2174/1567205012666141218123829
Mattila et al. Disease State Fingerprint for Evaluating the State of Alzheimer’s Disease in Patients. Journal of Alzheimer’s Disease, 2011. https://doi.org/10.3233/JAD-2011-110365
Koikkalainen and Lötjönen. Method for inferring the state of a system, U.S. Patent No. 7,840,510 B2
Lötjönen, Koikkalainen and Mattila. State Inference in a heterogeneous system, U.S. Patent No, 10,372,786 B2
All data transfer uses SSL encryption. Stored data are encrypted and anonymized.
More information is available in a separate security statement.
Supported web browsers:
- Google Chrome 61 or later
- Firefox 56 or later
- Internet Explorer 11 or later.
Recommended display resolution 1680 x 1050 or higher.
CE marked and excluded from the definition of a medical device in the U.S based on section 520(o)(1)(E) of the Food Drug and Cosmetic Act.
Indications for Use
cNeuro® cDSI is intended for use by health care professionals to aid in diagnosing patients with a suspected neurodegenerative disorder. Patient parameters and test results are entered manually by the healthcare practitioner or retrieved through integration with other hospital systems. The device suggests whether the patient’s condition meets the definition of different neurodegenerative disorders through a comparison of the patient’s data with data from patients previously diagnosed based on established guidelines. The software is intended for the purpose of enabling healthcare professionals to independently review the basis for such recommendations. It is not the intent that the healthcare professional relies primarily on the software’s recommendations to make a clinical diagnosis or treatment decision regarding an individual patient. Patient data may include biomarkers from cerebrospinal fluid and imaging, as well as results from various neuropsychological and clinical tests. The intended user profile covers healthcare professionals who work with patients being evaluated for a suspected neurodegenerative disease. The intended operational environment is an office-like environment with a computer.